RT Book, Section
A1 Passi, Monica
A1 Berrigan, Michael J.
A2 Freeman, Brian S.
A2 Berger, Jeffrey S.
SR Print(0)
ID 1135741169
T1 Polycythemia
T2 Anesthesiology Core Review: Part Two Advanced Exam
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259641770
LK accessanesthesiology.mhmedical.com/content.aspx?aid=1135741169
RD 2024/04/23
AB Polycythemia,  a  chronic  myeloproliferative  disorder,  affects  approximately  2.3  per  100,000  persons  per  year.  It  is  prevalent  in  all  age  groups  with  the  highest  incidence  occurring  in  the  seventh  and  eight  decades.  This  disorder,  arising  from  a  mutation  in  the  JAK2  gene,  gives  rise  to  the  proliferation  of  all  hematopoietic  precursors,  with  erythrocytosis  being  the  most  common  manifestation,  and  leukocytosis  and  thrombocytosis  more  rarer  presentations.  This  resultant  erythrocytosis  leads  to  abnormally  high  hematocrit,  predisposing  patients  to  hyperviscosity  of  the  blood  and  a  multitude  of  associated  complications.