RT Book, Section A1 Hess, Dean R. A1 Kacmarek, Robert M. SR Print(0) ID 1121735475 T1 Ventilator-Induced Lung Injury T2 Essentials of Mechanical Ventilation, 3e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 9780071771511 LK accessanesthesiology.mhmedical.com/content.aspx?aid=1121735475 RD 2024/04/18 AB ObjectivesDiscuss the primary factors that contribute to ventilator-induced lung injury (VILI).Discuss stress and strain as related to lung injury.Describe mechanisms whereby small tidal volumes and positive end-expiratory pressure (PEEP) modify VILI.Discuss the effect of an inappropriate ventilatory pattern on inflammatory mediator response and the translocation of cells and molecules.Describe the proposed relationship between VILI and multiple organ dysfunction syndrome (MODS).Discuss the clinical outcomes data to support the use of lung protective ventilatory strategies.