TY  - CHAP
M1  - Book, Section
TI  - Skeletal Muscle Contraction
A1  - de Jesus, Matthew
A2  - Freeman, Brian S.
A2  - Berger, Jeffrey S.
PY  - 2014
T2  - Anesthesiology Core Review: Part One Basic Exam
AB  - Voluntary  skeletal  muscle  contraction  occurs  when  an  electrical  signal  (action  potential)  travels  via  somatic  nerves  to  the  synaptic  cleft.  Here,  the  electrical  action  potential  opens  voltage-gated  calcium  channels,  and  calcium  causes  the  release  of  acetylcholine  (ACh)  into  the  synaptic  cleft.  The  ACh  travels  across  the  synaptic  cleft  binding  to  nicotinic  ACh  receptors,  which  when  activated,  allow  an  influx  of  sodium  ions  into  the  muscle  fiber  membrane.  The  intracellular  voltage  change  from  the  influx  of  sodium  transmits  an  action  potential  via  T-tubules  to  the  center  of  the  muscle  cell,  where  upon  reaching  the  sarcoplasmic  reticulum,  calcium  ions  are  released,  enabling  muscle  fibers  to  contract.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1102568844
ER  -