TY - CHAP M1 - Book, Section TI - Control of Breathing A1 - Levitzky, Michael G. A2 - Levitzky, Michael A2 - McDonough, Kathleen A2 - Kaye, Alan David A2 - Hall, Stanley PY - 2021 T2 - Clinical Physiology in Anesthetic Practice AB - Breathing is spontaneously initiated in the central nervous system. Neurons in the brainstem automatically generate a cycle of inspiration and expiration. This spontaneously generated cycle of inspiration and expiration can be modified, altered, or even temporarily suppressed by a number of mechanisms. As shown in Figure 33-1, these include reflexes arising in the lungs, the airways, and the cardiovascular system; information from receptors in contact with the cerebrospinal fluid; and commands from higher centers of the brain such as the hypothalamus, the centers of speech, or other areas in the cortex. The centers that are responsible for the generation of the spontaneous rhythmicity of inspiration and expiration are, therefore, able to alter their activity to meet the increased metabolic demand on the respiratory system during exercise or may even be temporarily superseded or suppressed during speech or breath holding. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/19 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1175535384 ER -