TY  - CHAP
M1  - Book, Section
TI  - Myelomeningocele
A1  - Waberski, Andrew T.
A1  - Reddy, Srijaya K.
A2  - Freeman, Brian S.
A2  - Berger, Jeffrey S.
PY  - 2016
T2  - Anesthesiology Core Review: Part Two Advanced Exam
AB  - Myelomeningocele  is  a  neural  tube  defect  that  disrupts  proper  neuralization  and  closure  of  the  spinal  column.  This  defect  occurs  at  4–6  weeks  gestation  and  results  in  evagination  of  the  dural  sac  with  neuronal  tissue.  Myelomeningoceles  are  the  most  common  neural  tube  defect,  with  3.4  out  of  every  10  000  live  births  being  affected.  Although  the  etiology  of  myelomeningocele  is  not  completely  understood,  low  levels  of  folic  acid  during  pregnancy  are  thought  to  play  a  role.  Prenatal  screening,  early  termination,  and  folic  acid  supplementation  have  decreased  the  incidence  of  myelomeningoceles.  Advances  in  fetal  screening  tests  including  maternal  alpha-fetoprotein  levels,  amniocentesis,  and  fetal  ultrasound  have  helped  identify  cases  of  myelomeningocele  allowing  for  earlier  interventions.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1135742544
ER  -