TY  - CHAP
M1  - Book, Section
TI  - Chapter 41. Preemptive Analgesia
A1  - Simopoulos, Thomas T.
A2  - Warfield, Carol A.
A2  - Bajwa, Zahid H.
Y1  - 2004
N1  - 
T2  - Principles & Practice of Pain Medicine, 2e
AB  - The  understanding  of  postoperative  pain  has  evolved  greatly  during  the  past  decade.  Many  laboratory  investigations  have  established  that  peripheral  tissue  injury  during  surgery  can  trigger  a  prolonged  state  of  spinal  cord  excitation.  A  reduction  in  neuronal  thresholds  in  the  central  nervous  system  (CNS)  is  thought  to  amplify  pain  in  postsurgical  patients.  Preemptive  analgesia  is  an  antinociceptive  treatment  targeted  to  block  CNS  hyperexcitability,  and  thereby  leads  to  a  reduced  postoperative  pain  state.  Despite  numerous  investigations,  the  clinical  relevance  of  such  treatment  is,  at  present,  an  issue  of  controversy.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=3416613
ER  -