TY  - CHAP
M1  - Book, Section
TI  - Thrombocytopenia and Thrombocytopathy
A1  - Epstein, Jeremy
A1  - Nguyen, Vinh
A2  - Freeman, Brian S.
A2  - Berger, Jeffrey S.
Y1  - 2016
N1  - 
T2  - Anesthesiology Core Review: Part Two Advanced Exam
AB  - Formation  of  a  hemostatic  plug  can  be  broken  down  into  primary  hemostasis  and  secondary  hemostasis.  Primary  hemostasis  involves  platelet  adhesion,  change  in  platelet  shape,  platelet  aggregation,  and  secretion  of  platelet  factors.  Secondary  hemostasis  involves  the  activation  of  the  coagulation  cascade.  Platelets  play  a  vital  role  in  the  formation  of  a  hemostatic  plug.  Platelets  are  originally  produced  in  the  bone  marrow  as  fragments  of  the  cytoplasm  from  megakaryocytes,  which  circulate  in  the  blood  for  7–10  days.  The  normal  circulating  platelet  count  is  150,000–450,000/μL  and  approximately  15,000–45,000/μL  platelets  are  made  per  day  to  maintain  a  steady  state.  At  any  given  time,  up  to  one-third  of  all  platelets  are  transiently  sequestered  in  the  spleen.  The  likelihood  of  bleeding  is  inversely  proportional  to  platelet  function  and  count.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessanesthesiology.mhmedical.com/content.aspx?aid=1135741198
ER  -