TY - CHAP M1 - Book, Section TI - Postobstructive Pulmonary Edema A1 - Ionescu, Adrian M. A1 - Ved, Sudha A2 - Freeman, Brian S. A2 - Berger, Jeffrey S. PY - 2014 T2 - Anesthesiology Core Review: Part One Basic Exam AB - Postobstructive pulmonary edema, also known as negative-pressure pulmonary edema (NPPE), is a serious, potentially fatal condition which commonly results from upper airway obstruction. More specifically, forced inspiration against an obstructed upper airway generates a large intrathoracic pressure gradient, an increased pulmonary vascular volume, and subsequently a significant increase in the pulmonary capillary transmural pressure, which produces a significant disruption of the capillary alveolar membrane. The movement of fluid across the pulmonary capillary bed can be further summarized by the Starling equation: Q = K × [(Pc– Pi) – σ (πc– πi)] (Q, flow across the pulmonary capillary bed; Pc, capillary hydrostatic pressure; Pi, interstitial hydrostatic pressure; πc, capillary oncotic pressure, and πi, interstitial oncotic pressure). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1102568359 ER -