TY - CHAP M1 - Book, Section TI - Pharmacological Management of Chronic Pain A1 - Bunch, Jennifer R. A1 - Qian, Xiang A2 - Longnecker, David E. A2 - Mackey, Sean C. A2 - Newman, Mark F. A2 - Sandberg, Warren S. A2 - Zapol, Warren M. PY - 2017 T2 - Anesthesiology, 3e AB - KEY POINTSComprehensive pain management focuses on improving patient functionality and quality of life by integrating pharmacologic treatment, interventional modalities, physical therapy, and cognitive-behavioral modification. Among them, pharmacological therapy remains the mainstay of treatment.Finding appropriate pharmacological treatments through a mechanism-based approach offers the best chance for a rational selection of proper therapies.Optimal use of medications requires a thorough understanding of their pharmacology as well as the ability to compare their effects through standardized study including meta-analysis and measures such as number needed to treat analysis.Opioid therapy presents unique challenges to the prescriber including pharmacologic tolerance, side effect, dependence, abuse, drug diversion, and medicolegal issues. Continuous monitoring and attention to the physician-patient relationship is vital.The future of pain practice involves combination therapy because a solo agent is rarely sufficient to manage pain. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1144137418 ER -