TY - CHAP M1 - Book, Section TI - Complex Regional Pain Syndrome A1 - Stanton-Hicks, Michael A1 - Abdi, Salahadin A2 - Bajwa, Zahid H. A2 - Wootton, R. Joshua A2 - Warfield, Carol A. PY - 2016 T2 - Principles and Practice of Pain Medicine, 3e AB - Ever since Claude Bernard implicated the sympathetic nervous system in sensation, its role in nociception has been the subject of debate.1 No one would argue with the fact that the sympathetic nervous system is intimately involved with the preservation of homeostasis and noxious challenges in humans, although the manner in which it influences the sensation of pain has, until recently, escaped explanation.2 Anatomically, the sympathetic nervous system constitutes a highly complex arrangement of preganglionic and postganglionic neurons that subserve specific and diverse functions of target organs, including enteric neurons, smooth muscle, syncytial muscle, and striated muscle.3 Physiologically, the sympathetic nervous system is associated in some way with both systemic and specific local reactions, which are expressed by supratentorial and confrontational aspects that are represented in the periaqueductal gray matter of the midbrain (e.g., nonopioid analgesia).4,5 In contrast, rest and quiescence are represented in the ventrolateral periaqueductal gray matter, being associated with endogenous opioid analgesia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/23 UR - accessanesthesiology.mhmedical.com/content.aspx?aid=1131934538 ER -