Skip to Main Content

++

INTRODUCTION

++

Choosing an antibiotic depends on the properties of the antibiotic and the nature of the pathogen. The following considerations are important in selecting the proper course of antimicrobial treatment:

++

  1. Identification of the pathogen determined with testing

  2. Susceptibility of the organism to a variety of antibiotics

  3. Seriously ill or immunocompromised patients should receive bactericidal rather than bacteriostatic drug

  4. Site of infection (ie, does the blood–brain barrier need to be crossed?)

  5. Patient limitations such as allergy, immunosuppression, hepatic failure, or renal dysfunction

  6. Use of multiple antimicrobials in combination

  7. Route of administration

  8. Duration of treatment

  9. Risk of development of resistant strains

  10. Cost

++

In general, narrow-spectrum antibiotics should be chosen before broad spectrum drugs to avoid disruption of the patient’s normal flora of bacteria. Normal bacterial flora are important as they can compete with pathogens for nutrients, produce antibacterial substances, and combat nosocomial-resistant organisms. The recommended dosing of antibiotics should be strictly followed. Morbidly obese patients may require increased dosing to achieve adequate tissue levels of antibiotics, while patients with hepatic or renal dysfunction may require decreased dosing. A listing of commonly used perioperative antibiotics can be found in Table 67-1.

++
Table Graphic Jump Location
TABLE 67-1   Common Perioperative Antibiotics 

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessAnesthesiology Full Site: One-Year Subscription

Connect to the full suite of AccessAnesthesiology content and resources including procedural videos, interactive self-assessment, real-life cases, 20+ textbooks, and more

$995 USD
Buy Now

Pay Per View: Timed Access to all of AccessAnesthesiology

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.