MOMO is an acronym for macrosomia, obesity,
macrocephaly, and ocular abnormalities. Macrocephaly and tall stature, delayed
bone development, generalized obesity, numerous ocular abnormalities (retinal coloboma and nystagmus), and
Only three cases described;
suggested to be a new mutation with autosomal dominant inheritance.
Two unrelated sibs were first described with
significant obesity, mental retardation, macrocephaly, delayed bone
maturation, retinal coloboma, nystagmus, and downward slant of palpebral
fissures. Tall stature, macrostomia, and delayed eruption of teeth.
Based on the few cases described,
special attention must be paid to the airways because of the generalized,
often morbid obesity. The increased risk of gastric content regurgitation must
be kept in mind in patients with severe obesity. The presence of macrocephaly may be associated with
macroglossia and potential difficult tracheal intubation. Difficulty in
mechanical ventilation preoperatively and postoperatively is possible in
presence of severe obesity.
Moretti-Ferreira D, Koiffmann CP, Listik M, et al: Macrosomia, obesity,
macrocephaly and ocular abnormalities (MOMO syndrome) in two unrelated
patients: Delineation of a newly recognized overgrowth syndrome. Am J Med Genet
Zannolli R, Mostardini R, Hadjistilianou T, et al: MOMO syndrome: A possible
third case. Clin Dysmorphol