Skip to Main Content

++

Very rare syndrome of premature aging facies combined with growth retardation.

++

Growth Retardation, Aged Facies, Normal Development, Decreased Subcutaneous Fat Syndrome.

++

Seven cases have been described worldwide. Probably autosomal dominant inheritance.

++

Patients present with intrauterine growth retardation and postnatal growth delay with normal mental development. There is decreased subcutaneous fat and thin or absent scalp hair. Main features involve the face, which seems prematurely aged with a triangular facies, prominent forehead, deep-set eyes, midfacial hypoplasia, prominent nasal septum, hypoplastic alar nasae, prominent ears, and thin lips.

++

Tracheal intubation and face-mask ventilation may be difficult because of anatomical abnormalities. Nasal intubation should be avoided secondary to small nares.

Marion RW, Goldberg RB, Young RS, et al: The GRANDDAD syndrome: A disorder combining growth delay, “aged facies,” normal development, and deficiency of subcutaneous fat. Am J Hum Genet 45(suppl):A53, 1989.

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessAnesthesiology Full Site: One-Year Subscription

Connect to the full suite of AccessAnesthesiology content and resources including procedural videos, interactive self-assessment, real-life cases, 20+ textbooks, and more

$995 USD
Buy Now

Pay Per View: Timed Access to all of AccessAnesthesiology

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.