Skip to Main Content


A disorder involving nail dysplasia and bone abnormalities.


Anonychia-Onychodystrophy with Hypoplasia/Absence of Distal Phalanges.


Extremely rare disorder described in a total of 11 members from only two families. Autosomal dominant inheritance.


The diagnosis is made based on family history and the characteristic clinical features of hand and nails, which include onychodystrophy that can progress to complete loss of nails, digitalization of the thumbs, fifth finger brachydactyly, and absent or hypoplastic distal phalanges of hands and feet.


Because the findings are limited to the hands, no specific anesthetic concerns are expected to arise from this disorder.


Coffin-Siris Syndrome: A congenital syndrome with growth and mental retardation, coarse facies, nail dysplasia and skeletal anomalies.

Cooks RG, Hertz M, Katznelson MB, et al: A new nail dysplasia syndrome with onychonychia and absence and /or hypoplasia of distal phalanges. Clin Genet 27:85, 1985.  [PubMed: 3978841]
Nevin NC, Thomas PS, Eedy DJ, et al: Anonychia and absence/ hypoplasia of distal phalanges (Cooks syndrome): Report of a second family. J Med Genet 32:638, 1995.  [PubMed: 7473658]

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.


About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessAnesthesiology Full Site: One-Year Subscription

Connect to the full suite of AccessAnesthesiology content and resources including procedural videos, interactive self-assessment, real-life cases, 20+ textbooks, and more

$995 USD
Buy Now

Pay Per View: Timed Access to all of AccessAnesthesiology

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.