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Disorder characterized by galactorrhea and amenorrhea.


Amenorrhea-Galactorrhea-Hyperprolactinemia Syndrome.


  • Type I = Chiari-Frommel Syndrome: persistent AGS after giving birth.
  • Type II = Ahumada-Del Castillo Syndrome (Argonz del Castillo-Ahumada Syndrome; Amenorrhea-Galactorrhea FSH Decrease Syndrome; Nonpuerperal Galactorrhea-Amenorrhea Syndrome): AGS not associated with pregnancy. Estrogen deficiency and decreased urinary gonadotropin levels.
  • Type III = Forbes-Albright Syndrome: AGS caused by chromophobe prolactin-producing adenoma of the pituitary.


Autosomal dominant.


Tumors resembling chromophobe adenomas of the pituitary gland with eosinophilic granulation on tetrachrome staining.


Secondary amenorrhea with galactorrhea. Enlargement of the sella turcica.


No known specific anesthetic considerations for this syndrome.

Rimoin DL, Schimke RN: Genetic Disorders of the Endocrine Glands. St. Louis, CV Mosby, 1971.

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