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Inhibition of the enzyme cyclooxgenase preventing synthesis of prostaglandin and thromboxane.
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Mild to moderate pain, inflammation, and fever.
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ASRA consensus guidelines: nonsteroidal anti-inflammatory drugs (NSAIDs) alone should not interfere with the performance of neuraxial blocks or the timing of neuraxial catheter removal.
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At many institutions, it is customary for the anesthesiology team to verbally confirm adequate hemostasis (and surgeon’s agreement) prior to administering IV NSAIDs.
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Nonselective COX-1 and COX-2 inhibitors and selective COX-2 inhibitors:
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