Skip to Main Content


The prognosis of cancer in children has improved dramatically over the past 40 years. Unlike many adult cancers, pediatric malignancies are often responsive to initial aggressive induction chemotherapy. The most common childhood cancer, acute lymphoblastic leukemia (ALL), was an almost uniformly fatal disease in the early 1950s. Long-term survival rates in children with ALL now exceed 70%. Children with cancer, however, frequently experience a variety of acute and chronic pains, which can be a result of cancer treatment or of the tumor itself.1 The treatment of cancer pain in children should involve a multidimensional approach that relies not only on medications for pain and symptom management, but also on cognitive-behavioral interventions and other nonpharmacologic therapies. This approach provides optimal pain control and addresses patients’ complex emotional needs related to grief and sense of loss.


In contrast to adults, children with cancer more frequently experience pain related to aspects of cancer treatment. This is in part because of higher rates of remission in children after initial chemotherapy induction and improved long-term survival rates in childhood cancers.1,2


Procedures such as bone marrow biopsies and aspirates, lumbar punctures, and central venous line insertions are common sources of distress and pain in children with cancer. Other sources of pain related to the treatment of cancer include painful mucositis, amputation pain, and painful neuropathies from surgery and chemotherapeutic agents.


Every attempt should be made to minimize distress, fear, and pain in children undergoing brief needle procedures and other more invasive procedures, since initial traumatic experiences with procedures tend to make subsequent procedures more distressing. In general, treatment of procedure-related pain should consist of the individualized use of combinations of cognitive-behavioral interventions, local anesthesia, conscious sedation, and general anesthesia.


There is ample evidence to support the use of cognitive-behavioral strategies in managing procedure-related pain in children with cancer. Through guided imagery, progressive muscle relaxation, and hypnosis, patients can direct their focus away from pain and the procedure and help reduce their experience of pain, fear, and discomfort. Young children or those with developmental deficiencies, however, may not have the cognitive abilities to use these techniques. Explaining the procedure in age-appropriate terms often helps to gain the child’s trust and confidence.


The use of local anesthetics and conscious sedation combined with cognitive-behavioral techniques can make procedures less terrifying for children. Applying EMLA (eutectic mixture of lidocaine and prilocaine) to the skin overlying intravenous catheter-insertion sites or lumbar puncture sites can reliably decrease the pain from needle insertion into the skin. This can allow less painful infiltration of local anesthetics deep to the dermis. For more invasive procedures or for children who experience significant distress with brief needle procedures, conscious sedation or general anesthesia should be used. Conscious sedation refers to a level of sedation where a child is comfortable but is able to maintain airway reflexes and spontaneous ventilation. Conscious sedation is often performed by ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.


About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessAnesthesiology Full Site: One-Year Subscription

Connect to the full suite of AccessAnesthesiology content and resources including procedural videos, interactive self-assessment, real-life cases, 20+ textbooks, and more

$995 USD
Buy Now

Pay Per View: Timed Access to all of AccessAnesthesiology

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.